There are today 115 (92) companies plus partners developing 126 (111) gene therapy drugs in 249 (208) developmental projects in cancer. In addition, there are 4 (6) suspended drugs and the accumulated number of ceased drugs over the last years amount to another 90 (49) drugs. Gene Therapy In Oncology Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 88 (80) different targets. These targets are further categorized on in the software application by 39 (35) classifications of molecular function and with pathway referrals to BioCarta, KEGG and NetPath. Figures in brackets are comparative data from last year.

Find and sort drugs by twelve different parameters plus free text search field. Our dynamic report generator lets you with ease and speed generate html reports directly in your web browser, whether it is a single drug profile or an entire search you want have a report of.

How May Drug Pipeline Update Be of Use?

Show investors/board/management that you are right on top of drug development progress in your therapeutic area.
Find competitors, collaborations partners, M&A candidates etc.
Jump start competitive drug intelligence operations
Excellent starting point for world wide benchmarking
Compare portfolio and therapy focus with your peers
Speed up pro-active in-/out licensing strategy work
Fast and easy way of tracking drugs using search engines; just one click from inside the application and you may search the World Wide Web and PubMed for any drug.

Drug Pipeline Update is delivered to you as a downloadable application, which requires no installation on your computer. Please read more about application features and system requirements below.

Drug Pipeline Update at a Glance

Investigators

Includes more than 115 (92) principal investigators plus their collaborators. There is direct access from inside the application to web pages of all principal investigators.

Note: You are able to sort and find drugs according to investigators and partners from drop-down menus in the application. You may also sort and find drugs according to country of investigator.

Drug name & Synonyms

Lists commercial, generic and code names for drugs.

Developmental stage

This Drug Pipeline Update contains 126 (111) gene therapy drugs in development, which have a total of 249 (208) developmental projects in cancer. In addition there are suspended and ceased drugs.

Pipeline Breakdown According to Number of Drugs

Marketed# 3 (1)

Pre-registration# 0 (1)

Phase III# 6 (6)

Phase II# 35 (32)

Phase I# 34 (28)

Preclinical# 69 (59)

No Data# 1 (5)

Suspended# 4 (6)

Ceased# 90 (49)

Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application.

Indications

Included gene therapy drugs are also in development for 53 (49) other indications, where of 47 (42) are different cancer indications.

Note: You are able to find and sort drugs according to type of indication from drop-down menu in the application.

Targets

Identified drugs are linked to more than 88 (80) different targets, divided into 39 (35) classifications of molecular function:

Carboxypeptidase activity
Catalytic activity
Cell adhesion molecule activity
Complement activity
Cysteine-type peptidase activity
Cytokine activity
DNA binding
DNA repair protein
DNA-directed DNA polymerase activity
Extracellular matrix structural constituent
Growth factor activity
GTPase activity
Isomerase activity
Kinase binding
Kinase regulator activity
Ligand-dependent nuclear receptor activity
Ligase activity
Metallopeptidase activity
MHC class I receptor activity
Molecular function unknown
Oxidoreductase activity
Peptidase activity
Peptide hormone
Protein binding
Protein serine/threonine kinase activity
Protein-tyrosine kinase activity
Receptor activity
Receptor binding
RNA-directed DNA polymerase activity
Serine-type peptidase activity
Structural constituent of cytoskeleton
Structural molecule activity
Superoxide dismutase activity
Transcription factor activity
Transcription regulator activity
Translation regulator activity
Transmembrane receptor activity
Transmembrane receptor protein tyrosine kinase activity
Transporter activity

Identified targets are categorized into 11 (10) different primary and alternate sub-cellular localizations:

Centrosome
Cytoplasm
Endoplasmic reticulum
Endosome
Extracellular
Golgi apparatus
Mitochondrion
Nucleolus
Nucleus
Plasma membrane
Secreted

Note: You are able to find and sort drugs according to target gene name, molecular function of target, and target localization from drop-down menus in the application.

Target Expression Profile

Direct links are provided from inside the application to 90 (75) protein expression profiles of 59 (50) drug targets in various human tissues and cancer types, cell lines and primary cells, including up to:

48 different normal tissue types
20 different types of cancer
47 cell lines
12 samples of primary blood cells

Pathway Referals

Identified targets have been cross referenced against their involvement in different cellular pathways, according to BioCarta, KEGG and NetPath.

BioCarta# 145 (121) Pathways
KEGG# 83 (81) Pathways
NetPath# 14 (12) Signaling Pathways

Note: You are able to find and sort drugs according to targeted pathways from drop-down menus in the application.

Mechanism

In total there are 87 (79) different drug mechanism of action represented in this Drug Pipeline Update.

Note: You are able to find and sort drugs according to mechanism of action from drop-down menu in the application.

Compound

Identified drug compounds are described by:

Compound type, Chemical name, CAS Number and molecular weight

Note: You are able to sort and find drugs according to compound type from drop-down menu in the application.

Drug Profile

Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information:

Drug Name & Synonyms

Presentation of drug name and synonyms

Principal Investigator & Partners

Presentation of principal investigator and partners

Target and Molecular Function of Target

Described target(s) is/are presented with:

Official Gene Symbol - Official Gene Name [Species/Homo Sapiens] - Molecular Function

Target Localization

Described target(s) is/are presented with primary and alternate localizations.

Target Expression Profiles

Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to:

48 different normal tissue types

20 different types of cancer

47 cell lines

12 samples of primary blood cells

Targeted Pathways

Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, and NetPath.

Mechanism

Drug mechanism of action

Developmental Projects

Summary field of developmental projects for the drug, including indication, developmental stage and status.

Example:

Cancer, myeloma - Phase II Clinical Trial - Active

Cancer, prostate - Phase III Clinical Trial - Ceased

Drug Description

Short introduction to drug

Compound Data

Compound type, Chemical name, CAS Number and molecular weight

Patent Data

Available patent information related to the drug is presented here.

Business & Markets

Collaborations and deals

Approvals and submissions

Analyst comments

Phase III Data

Available Phase III development data, developmental history and scientific data.

Phase II Data

Available Phase II development data, developmental history and scientific data.

Phase I Data

Available Phase I development data, developmental history and scientific data.

Preclinical Data

Available preclinical development data, developmental history and scientific data.

Licensing Information

Availability for licensing

Application Features

Use 13 different parameters, available in drop-down menus, to find and sort among drugs

Drug status
Clinical Trial Status
Principle Investigator
Partners
Indication
Developmental Stage
Compound Type
Mechanism
Target
Molecular Function of Target
Target Localization
Targeted Pathways
Free text search of entire drug profile contents

Direct linkage from inside the application to related internet resources

Drug data is linked to search engines like Google and PubMed
Drug target data is linked directly to BioCarta, Human Protein Atlas, KEGG, and NetPath
Direct links to company web pages of principal investigators

Dynamic Report Generator

Our dynamic report generator lets you with ease and speed generate html reports directly in your web browser (Internet Explorer), whether it is a single drug profile or an entire search you want have a report of.

System Requirements

Operating system: Windows (2000/XP/Vista/7) and Mac OS X 10.6 (Snow Leopard) and OS X 10.7 (Lion)
Browser Application (Internet Explorer)
Internet access (to access related internet resources)

Please note: due to the nature of this report the number of pages and toc are not available

Pharmaceutical Market Research

Gene Therapy in Oncology Drug Pipeline Update 2011