Basic Pharmacokinetics

Basic Pharmacokinetics

First edition

Sunil S Jambhekar - Professor and Acting Chair, Department of Pharmaceutical Sciences, LECOM-Bradenton School of Pharmacy, Florida, USA and Philip Breen - Associate Professor of Pharmaceutics, College of Pharmacy, University of Arkansas for Medical Sciences, USA

Basic Pharmacokinetics enables the reader to become adept at solving pharmacokinetic problems arising in drug therapy and to understand the applications and utility of equations in clinical practice.

It is an invaluable textbook for undergraduate and graduate students in pharmacy, medicine and pharmaceutical sciences.

Basic Pharmacokinetics provides an understanding of the principles of pharmacokinetics and biopharmaceutics and of how these principles can be applied to achieve successful drug therapy. The application of principles and equations are illustrated by relevant data and chapters conclude with related problem sets and problem solving exercises.

Novel features of this text include:

• the use of profiles (sketches of relationships among pharmacokinetic variables and parameters) to help the reader understand pharmacokinetics intuitively
• a set of learning objectives provided at the beginning of each chapter
• a complete review of mathematical tools required to practice pharmacokinetics
• chapters linking dosage form design and physicochemical properties of drugs to pharmacokinetics
• intuitive and physiological approaches to understanding clearance
• a table of rules for converting between oral, intravenous, loading, and maintenance dosing regimens
• a 3-dimensional representation of pharmacokinetics/pharmacodynamics (PKPD)
• a chapter including an extensive list of cytochrome P 450 and transporter- mediated drug interactions
• a chapter outlining the pharmacokinetics of the latest biotechnology drugs.

Contents

• 1. Overview
• 2. Mathematical Review
• 3. Intravenous Bolus Administration
• 4. Clearance Concepts
• 5. Drug Absorption From the Gastrointestinal Tract
• 6. Extravascular Routes of Drug Administration
• 7. Bioavailability/bioequivalence
• 8. Factors Affecting Drug Absorption
• 9. Gastrointestinal Absorption
• 10. Continuous Intravenous Infusion
• 11. Multiple Dosing
  • Intravenous Bolus Administration
• 12. Multiple Dosing
  • Extravascular Routes of Drug Administration
• 13. Two-compartment Model
• 14. Multiple Intermittent Infusions
• 15. Non Linear Pharmacokinetics
• 16. Drug Interactions
• 17. Pharmacokinetic and Pharmacodynamic Relationships
• 18. Pharmacokinetics and Pharmacodynamics of Biotechnology
• Appendix

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