Emerging Opportunities with Cannabinoids

Product Code ESP00567
Publication Date September 2008
Publisher Espicom
Product Type Report
Pages 74
ISBN Number 978-1-85822-328-5

Emerging Opportunities with Cannabinoids

This invaluable briefing provides a critical and far-reaching examination of current cannabinoid products and areas of unmet clinical need where the use of cannabinoids could be clinically beneficial and commercially profitable.

Contents

  • Introduction
  • CB1 agonists
    • Cannabinoid agonists and CB1 specific agonists in development
  • Emesis
    • Market size and growth
    • Growth drivers and market risks
    • Current and future drug therapies
  • Cachexia
    • Market size and growth
    • Population forecasts
      • HIV/AIDS cachexia:
      • Forecast number of patients with cachexia associated with HIV/AIDS ('000s)
      • Cancer cachexia:
  • Growth drivers and market risks
    • HIV/AIDS cachexia:
    • Cancer cachexia:
  • Current and future drug therapies
    • HIV/AIDS cachexia:
    • Cancer cachexia:
  • Pain
    • Market size and growth
    • Neuropathic pain:
    • Population forecasts
    • Growth drivers and market risks
    • Current and future drug therapies
  • Traumatic brain injury
  • Cancer
  • CB2 agonists
    • CB2 agonists in development
  • Pain and inflammation
    • Market size and growth
    • Population forecasts
      • Forecast number of patients with osteoarthritis (millions)
  • Growth drivers and market risks
  • Current and future drug therapies
  • Blood cancers
  • CB1 antagonists
    • CB1 antagonists in development
  • Obesity
  • Market size and growth
    • Increasing prevalence of obesity in the US
    • Rates of obesity in five major European countries
  • Population forecasts
    • Forecast number of obese adults in millions
  • Growth drivers and market risks
  • Current and future agents
  • Smoking cessation
    • Market size and growth
    • Trends in per capita cigarette consumption
  • Population forecasts
    • Forecast number of smokers (in millions) in major developed markets
  • Growth drivers and market risks
    • Current and future agents
  • Schizophrenia
  • Parkinson's disease
  • CB2 antagonists
  • Endocannabi noid deactivation i nhibi tors
    • FAAH inhibitors in development
  • Drug p rofiles
    • Acomplia (rimonabant)
    • Novelty/rationale for mechanism of action
    • Proof of concept/clinical data
    • Management/clinical expertise
    • Competition within the marketplace/gaining share of voice
    • Risks associated with developing a drug within a therapeutic class
    • Filings and approval
    • Sales forecasts and assumptions
    • Forecast Acomplia sales by use (US$ millions):
    • Competitor ratio analysis
    • taranabant (MK 0364)
    • Novelty/rationale for mechanism of action
    • Proof of concept/clinical data
    • Management/clinical expertise
    • Competition within the marketplace/gaining share of voice
    • Risks associated with developing a drug within a therapeutic class
    • Filings and approval
    • Sales forecasts and assumptions
    • Forecast taranabant sales by use (US$ millions):
    • Competitor ratio analysis
    • otenabant (CP-945,598)
    • Novelty/rationale for mechanism of action
    • Proof of concept/clinical data
    • Management/clinical expertise
    • Competition within the marketplace/gaining share of voice
    • Risks associated with developing a drug within a therapeutic class
    • Filings and approval
    • Sales forecasts and assumptions
    • Forecast otenabant sales by use (US$ millions):
    • Competitor ratio analysis
    • ibipinabant (BMS-646256; SLV-319)
    • Novelty/rationale for mechanism of action
    • Proof of concept/clinical data
    • Management/clinical expertise
    • Competition within the marketplace/gaining share of voice
    • Risks associated with developing a drug within a therapeutic class
    • Filings and approval
    • Sales forecasts and assumptions
    • Forecast ibipinabant sales by use (US$ millions):
    • Competitor ratio analysis
    • surinabant (SR-147778)
    • Novelty/rationale for mechanism of action
    • Proof of concept/clinical data
    • Management/clinical expertise
    • Competition within the marketplace/gaining share of voice
    • Risks associated with developing a drug within a therapeutic class
    • Filings and approval
    • Sales forecasts and assumptions
    • Competitor ratio analysis
    • Marinol (dronabinol)
    • Novelty/rationale for mechanism of action
    • Proof of concept/clinical data
    • Marinol Dose: Response Frequency and Adverse Experiences*
    • (N = 750 treatment courses)
    • Cachexia in A IDS patients:
    • Management/clinical expertise
    • Competition within the marketplace/gaining share of voice
    • Risks associated with developing a drug within a therapeutic class
    • Filings and approval
    • Sales forecasts and assumptions
    • Forecast Marinol sales by use (US$ millions):
    • Competitor ratio analysis
    • Cesamet (nabilone)
    • Novelty/rationale for mechanism of action
    • Proof of concept/clinical data
    • Management/clinical expertise
    • Competition within the marketplace/gaining share of voice
    • Risks associated with developing a drug within a therapeutic class
    • Filings and approval
    • Sales forecasts and assumptions
    • Forecast Cesamet sales by use (US$ millions):
    • Competitor ratio analysis
    • Sativex (tetrahydrocannabinol and cannabidiol)
    • Novelty/rationale for mechanism of action
    • Proof of concept/clinical data
    • Management/clinical expertise
    • Competition within the marketplace/gaining share of voice
    • Risks associated with developing a drug within a therapeutic class
    • Filings and approval
    • Sativex development overview
    • Sales forecasts and assumptions
    • Forecast Sativex sales by use (US$ millions):
    • Competitor ratio analysis
    • cannabinor (PRS-211,375)
    • Novelty/rationale for mechanism of action
    • Proof of concept/clinical data
    • Management/clinical expertise
    • Competition within the marketplace/gaining share of voice
    • Risks associated with developing a drug within a therapeutic class
    • Filings and approval
    • Sales forecasts and assumptions
    • Competitor ratio analysis
  • KN38-7271
    • Novelty/rationale for mechanism of action
    • Proof of concept/clinical data
    • Management/clinical expertise
    • Competition within the marketplace/gaining share of voice
    • Risks associated with developing a drug within a therapeutic class
    • Filings and approval
    • Sales forecasts and assumptions
    • Competitor ratio analysis
  • drinabant (AVE 1625)
    • Novelty/rationale for mechanism of action
    • Proof of concept/clinical data
    • Management/clinical expertise
    • Competition within the marketplace/gaining share of voice
    • Risks associated with developing a drug within a therapeutic class
    • Filings and approval
    • Sales forecasts and assumptions
    • Competitor ratio analysis
  • CRA analysis
    • Methodology
    • Overview
    • Cannabinoid agonists
      • CRA for cannabinoid agonists
    • CB1 antagonists
      • CRA for CB1 antagonists
      • Cannabinoids on the market and in development
  • APPEND IX I
  • Abbreviations