Our new report examines current and future prospects for the age-related macular degeneration (AMD) and diabetic retinopathy (DR) pharmaceutical markets. The global market for AMD and DR drugs exceeded $2.5bn in 2009, with growth from previous years. We predict that the overall market will expand from 2010 onwards. The rising prevalence of AMD and DR is due to aging populations worldwide and other changes. In particular, the world is facing a "diabetes epidemic", with soaring numbers of people with diabetes and related complications, including diabetic retinopathy.

In particular, Macular Degeneration (AMD) and Diabetic Retinopathy Pharmaceutical Market 2010-2025 covers market prospects for the following agents:

Lucentis
Visudyne
Macugen
Avastin.

Our report examines prospects for the retinal disorders market over the coming 15 years. The commercial success of Lucentis in treating wet AMD illustrates the high rewards for successful treatments. Our analyses reveal that there are commercial opportunities for the treatment of geographic atrophy (advanced dry AMD) and for wet AMD, among other disorders. There is a need for advantages over existing therapies, for improved clinical outcomes and ease of dosing. A large potential market for pharmacological treatment of diabetic retinopathy, AMD and other retinal disorders exists.

Un-met and under-met therapeutic needs provide an impetus to drug developers, with high technological and commercial potential in this sector, our study reveals. What impact will monoclonal antibodies and steroid implants have on the future market? Which products are most likely to meet therapeutic needs in future years? Can newer therapies compete successfully with established treatments? How will Avastin affect the market share of Lucentis, and what are the implications for the future market? Our new report covers such questions, providing the information that you need.

Comprehensive analysis of the global AMD and DR sectors

Macular Degeneration (AMD) and Diabetic Retinopathy Pharmaceutical Market 2010-2025 examines those sectors through a comprehensive review of information sources. We harness primary and secondary research. This report provides unique sales forecasts, market share analyses, discussions of R&D pipeline developments and analyses of commercial drivers and restraints, including a SWOT analysis. There are over 75 tables and figures included, as well as three interviews with industry experts. The result is a comprehensive market- and industry-centred study, with detailed analyses and informed opinion to benefit your work.

Why you should buy this report?

This report gives you the following benefits in particular:

You will receive a comprehensive analysis of the prospects for age-related macular degeneration (AMD) and diabetic retinopathy (DR) drugs from 2010 to 2025, including predicted revenues, growth rates and other data by group and sector
You will receive predicted revenues, growth rates and other data for leading products from 2010 to 2025, with discussions and other supporting information
You will find out the prospects for Lucentis in the face of competition from off-label use of Avastin, with supporting market analyses
You will receive sales forecasts for leading national markets (US, Japan, France, Germany, UK, Spain, Australia, Canada, China and India) from 2010 to 2025
You will identify R&D pipeline developments and up-and-coming products, with supporting discussions
You will discover the drivers, restraints, competition and opportunities influencing the AMD and DR treatment sectors
You will investigate under-met clinical needs, with therapeutic requirements and commercial opportunities discussed
You will discover expert views from our survey, including full interview transcripts
You will find out where the AMD and DR sectors are heading - technologically and commercially - from 2010 onwards.

You can obtain this report today.

This report is essential reading for anybody interested in the industry and market for treating eye disorders, especially retinal disorders. With expanding patient populations and under-served needs, this sector holds potential for further revenue growth and innovation from 2010 onwards. Our new study reveals prospects for existing competitors and potential market entrants. Do you want to harness those opportunities? You can stay ahead by ordering this report today.

1. Executive Summary
- 1.1 AMD & Diabetic Retinopathy Market Review
- 1.2 Aim, Scope and Format of the Report
- 1.3 Chapter Outlines
- 1.4 Research and Analysis Methods
2. Macular Degeneration and Diabetic Retinopathy
- 2.1 Vision
  - 2.1.1 The Human Eye
  - 2.1.2 The Retina and the Vision Process
- 2.2 Age-Related Macular Degeneration (AMD)
  - 2.2.1 Early Stages of AMD
  - 2.2.2 Advanced Dry AMD (Geographic Atrophy)
  - 2.2.3 Wet AMD
  - 2.2.4 Causes and Risk Factors for AMD
- 2.3 Diabetic Retinopathy (DR)
  - 2.3.1 Causes and Types of Diabetic Retinopathy
  - 2.3.2 Non-Proliferative Diabetic Retinopathy
  - 2.3.3 Diabetic Macular Oedema
  - 2.3.4 Proliferative Diabetic Retinopathy (PDR)
  - 2.3.5 Risk Factors for Diabetic Retinopathy
- 2.4 Diagnosis
- 2.5 Epidemiology
- 2.6 Other Retinal Disorders
3. The World Market for AMD and Diabetic Retinopathy Drugs
- 3.1 World AMD and DR Market Forecasts 2010-2025
- 3.2 AMD Market Forecast 2010-2025
- 3.3 Diabetic Retinopathy Market
- 3.4 Market Shares
- 3.5 Leading Companies in the Sector
4. Treatments for AMD and Diabetic Retinopathy
- 4.1 Treatment of Wet AMD
  - 4.1.1 Visudyne
    - 4.1.1.1 Visudyne: Forecast and Analysis 2010-2025
  - 4.1.2 Macugen
    - 4.1.2.1 Macugen: Forecast and Analysis 2010-2025
  - 4.1.3 Retaane
  - 4.1.4 Lucentis
    - 4.1.4.1 Lucentis: Forecast and Analysis 2010-2025
  - 4.1.5 Avastin
    - 4.1.5.1 Avastin: Forecast and Analysis 2010-2025
- 4.2 Treatment of Dry AMD
  - 4.2.1 Nutritional Supplements
  - 4.2.2 Intraocular Lenses
- 4.3 Treatments for Diabetic Retinopathy
  - 4.3.1 Laser and Other Surgical Treatments
  - 4.3.2 Triamcinolone Acetonide
  - 4.3.3 Lisinopril
  - 4.3.4 VEGF Inhibitors
  - 4.3.5 Dobesilate
5. AMD and Diabetic Retinopathy: Leading National Markets
- 5.1 US: Sales Prospects 2010-2025
- 5.2 France: Sales Prospects 2010-2025
- 5.3 Japan: Sales Prospects 2010-2025
- 5.4 Germany: Sales Prospects 2010-2025
- 5.5 UK: Sales Prospects 2010-2025
- 5.6 Spain: Sales Prospects 2010-2025
- 5.7 Australia: Sales Prospects 2010-2025
- 5.8 Canada: Sales Prospects 2010-2025
- 5.9 China: Sales Prospects 2010-2025
- 5.10 India: Sales Prospects 2010-2025
- 5.11 Comparing the National Markets
6. Issues Affecting the AMD and DR Pharmaceutical Markets
- 6.1 SWOT Analysis of the AMD and DR Pharmaceutical Markets
- 6.2 Intense Research and Development Activity
  - 6.2.1 New Drug Formulations
  - 6.2.2 Sustained-Release Ocular Implants
  - 6.2.3 Novel Biologic Drugs
  - 6.2.4 New Ophthalmic Therapeutic Applications for Drugs
- 6.3 The Avastin-Lucentis Debate
  - 6.3.1 Avastin and Lucentis
  - 6.3.2 Off-Label Retinal Applications of Avastin
  - 6.3.3 History of Avastin Use for Wet AMD
  - 6.3.4 The CATT Study
  - 6.3.5 The Future for Off-Label Avastin Use
- 6.4 Aging of the World Population Increases Demand for Treatments
- 6.5 Prevalence of Retinal Disorders
  - 6.5.1 Prevalence of AMD in 2009
  - 6.5.2 AMD Prevalence 2009-2025
  - 6.5.3 Prevalence of Diabetes, Proliferative Diabetic Retinopathy and Diabetic Macular Oedema, 2009
  - 6.5.4 Prevalence of Diabetic Retinopathy 2009-2025
- 6.6 Reimbursement for AMD and Diabetic Retinopathy Pharmaceuticals
  - 6.6.1 Pressure on Healthcare in Current Difficult Economic Environment
  - 6.6.2 Prospects for Reimbursement for AMD and DR Drugs
- 6.7 Diagnosis and Screening for Retinal Disorders
- 6.8 Laser and Surgical Treatments for Diabetic Retinopathy Will Compete with New Drugs
  - 6.8.1 Current Laser Treatments
  - 6.8.2 Will Drugs Replace Laser Therapy?
7. The AMD and Diabetic Retinopathy R&D Pipelines
- 7.1 VEGF Trap-Eye/Aflibercept (Regeneron/Bayer)
- 7.2 Ozurdex/SK-0503 (Allergan/Sanwa Kagaku Kenkyusho)
- 7.3 Bevasiranib (Opko)
- 7.4 Avastin and Lucentis Comparison Trials (CATT)
- 7.5 PF-4523655 (Quark/Pfizer)
- 7.6 Votrient (pazopanib) (GSK)
- 7.7 Zybrestat (Oxigene/Symphony ViDA)
- 7.8 Sirolimus (MacuSight/Santen)
- 7.9 Iluvien (Alimera/pSivida)
- 7.10 NT-501 (Neurotech)
- 7.11 OT-551 (Othera)
- 7.12 Lucentis (Novartis)
- 7.13 Macugen (Pfizer)
- 7.14 Vitreosolve (Vitreoretinal Technologies)
- 7.15 Microplasmin (ThromboGenics)
- 7.16 Arxxant (ruboxistaurin, Eli Lilly/Alcon/Takeda)
- 7.17 Stem Cells
8. Opinion from Industry Experts
- 8.1 Edward Danse, President and CEO, Neurotech
  - 8.1.1 Retinal Disorders with Greatest Unmet Patient Need
  - 8.1.2 Neurotech's AMD Pipeline
  - 8.1.3 Progress of NT-501 Clinical Trials in Geographic Atrophy Patients
  - 8.1.4 Screening Programmes for AMD
  - 8.1.5 Potential Lifetime of NT-501 in the Eye
  - 8.1.6 Other Potential Treatments for Geographic Atrophy
  - 8.1.7 Potential Use of NT-501 in Diabetic Retinopathy
- 8.2 Ken Green, Ph.D., Chief Scientific Officer, and Dave Holland, Founder/VP Marketing, Alimera Sciences
  - 8.2.1 Main Unmet Clinical Needs Among Diabetic Retinopathy Patients
  - 8.2.2 Development of Iluvien for Diabetic Macular Oedema
  - 8.2.3 Reimbursement Prospects for Corticosteroid Inserts
  - 8.2.4 Future for Laser Therapy in Diabetic Retinopathy
  - 8.2.5 Possible Future Treatment for Dry AMD and Geographic Atrophy
  - 8.2.6 Clinical Trials of Iluvien for Wet AMD and RVO
- 8.3 Dr Al Reaves, Ph.D., Senior Vice President of Clinical Development, Othera Pharmaceuticals
  - 8.3.1 Othera's Geographic Atrophy Drug: OT-551
  - 8.3.2 New Drugs for Retinal Disorders Currently with No Treatments
9. Conclusions
- 9.1 AMD and Diabetic Retinopathy
- 9.2 Increasing Prevalence of AMD and Diabetic Retinopathy
- 9.3 Current Treatments for AMD and Diabetic Retinopathy
- 9.4 The AMD and DR Pharmaceutical Market in 2009
- 9.5 AMD and Diabetic Retinopathy Pharmaceutical Market Forecast, 2010-2025
- 9.6 Lucentis Market Forecast, 2010-2025
- 9.7 The AMD R&D Pipeline
- 9.8 The Diabetic Retinopathy R&D Pipeline
- 9.9 Concluding Remarks
List of Tables
- Table 2.1 Causes of Blindness Worldwide, 2007
- Table 2.2 Wet AMD Types
- Table 2.3 AMD and DR Diagnosis Methods
- Table 2.4 Incidence and Prevalence of Advanced AMD & DR, 2009
- Table 2.5 Cases of Advanced AMD by Age Group, 2009
- Table 2.6 Cases of AMD by Age Group, 2009
- Table 2.7 Cases of DR by Age Group, 2009
- Table 2.8 Other Retinal Disorders
- Table 3.1 AMD & DR Pharmaceutical Markets, 2009
- Table 3.2 AMD and DR Markets: Revenue Forecasts, 2010-2025
- Table 3.3 AMD Pharmaceutical Market: Revenue Forecast, 2010-2025
- Table 3.4 DR Pharmaceutical Market: Revenue Forecast, 2010-2025
- Table 3.5 AMD and DR: Market Shares, 2010-2025
- Table 3.6 AMD & DR Pharmaceutical Markets: Leading Companies, 2009
- Table 4.1 AMD and DR Pharmaceutical Markets: Revenue Forecasts, 2010-2025
- Table 4.2 Visudyne Sales Breakdown, 2009
- Table 4.3 Visudyne: Revenue Forecast, 2010-2025
- Table 4.4 Macugen: Revenue Forecast, 2010-2025
- Table 4.5 Lucentis: Regulatory Approval and Launch Dates
- Table 4.6 Lucentis: Revenue Forecast, 2010-2025
- Table 4.7 Avastin: Revenue Forecast, 2010-2025
- Table 5.1 AMD & DR Market: Sales in Leading National Markets, 2009
- Table 5.2 The US AMD & DR Market: Revenue Forecast, 2010-2025
- Table 5.3 French AMD & DR Market: Revenue Forecast, 2010-2025
- Table 5.4 Proportion of Leading Markets' Populations over 65, 2010 and 2030
- Table 5.5 Japanese AMD & DR Market: Revenue Forecast, 2010-2025
- Table 5.6 German AMD & DR Market: Revenue Forecast, 2010-2025
- Table 5.7 UK AMD & DR Market: Revenue Forecast, 2010-2025
- Table 5.8 Spanish AMD & DR Market: Revenue Forecast, 2010-2025
- Table 5.9 Australian AMD & DR Market: Revenue Forecast, 2010-2025
- Table 5.10 Canadian AMD & DR Market: Revenue Forecast, 2010-2025
- Table 5.11 Chinese AMD & DR Market: Revenue Forecast, 2010-2025
- Table 5.12 Indian AMD & DR Market: Revenue Forecast, 2010-2025
- Table 5.13 Comparison of Leading National Markets: Revenue Forecasts, 2010-2025
- Table 6.1 SWOT Analysis of Age-Related Macular Degeneration & Diabetic Retinopathy Pharmaceutical Market, 2010
- Table 6.2 World Population Aging, 2009-2025
- Table 6.3 Number of Over-60s in Selected Countries, 2009 and 2025
- Table 6.4 AMD Incidence, 2009-2025
- Table 6.5 DR Incidence, 2009-2025
- Table 7.1 Key Late-Stage AMD Pipeline Drugs, 2010
- Table 7.2 Selected Early-Stage AMD Pipeline Drugs, 2010
- Table 7.3 Lucentis Clinical Trials in Progress, 2010
- Table 7.4 Key Late-Stage Diabetic Retinopathy Pipeline Drugs, 2010
- Table 7.5 Selected Early-Stage DR Pipeline Drugs, 2010
- Table 9.1 AMD & DR: Incidence Rates, 2009 and 2025
List of Figures
- Figure 2.1 Leading Causes of Blindness Worldwide, 2007
- Figure 2.2 How AMD Progresses
- Figure 2.3 Incidence and Prevalence of Advanced AMD & DR, 2009
- Figure 2.4 Proportion of Advanced AMD Cases by Age Group, 2009
- Figure 2.5 Proportion of AMD Cases by Gender, 2009
- Figure 2.6 Cases of DR by Age Group, 2009
- Figure 3.1 AMD and DR Pharmaceutical Markets, 2009
- Figure 3.2 AMD and DR Markets: Revenue Forecasts, 2010-2025
- Figure 3.3 AMD Pharmaceutical Market: Revenue Forecast, 2010-2025
- Figure 3.4 DR Pharmaceutical Market: Revenue Forecast, 2010-2025
- Figure 3.5 AMD and DR: Market Shares, 2010-2025
- Figure 3.6 AMD and DR Pharmaceutical Markets: Leading Companies, 2009
- Figure 4.1 Visudyne: Sales Breakdown, 2009
- Figure 4.2 Visudyne: Revenue Forecast, 2010-2025
- Figure 4.3 Macugen: Revenue Forecast, 2010-2025
- Figure 4.4 Lucentis: Revenue Forecast, 2010-2025
- Figure 4.5 Avastin: Revenue Forecast, 2010-2025
- Figure 5.1 AMD & DR Market Shares of Ten Leading Countries, 2009
- Figure 5.2 US AMD & DR Market: Revenue Forecast, 2010-2025
- Figure 5.3 Proportion of Leading Markets' Populations Aged over 65, 2010 and 2030
- Figure 5.4 French AMD & DR Market: Revenue Forecast, 2010-2025
- Figure 5.5 Japanese AMD & DR Market: Revenue Forecast, 2010-2025
- Figure 5.6 German AMD & DR Market: Revenue Forecast, 2010-2025
- Figure 5.7 UK AMD & DR Market: Revenue Forecast, 2010-2025
- Figure 5.8 Spanish AMD & DR Market: Revenue Forecast, 2010-2025
- Figure 5.9 Australian AMD & DR Market: Revenue Forecast, 2010-2025
- Figure 5.10 Canadian AMD & DR Market: Revenue Forecast, 2010-2025
- Figure 5.11 Chinese AMD & DR Market: Revenue Forecast, 2010-2025
- Figure 5.12 Indian AMD & DR Market: Revenue Forecast, 2010-2025
- Figure 5.13 Leading Country Markets (Upper Tier): Revenue Forecasts, 2010-2025
- Figure 5.14 Leading Country Markets (Lower Tier): Revenue Forecasts, 2010-2025
- Figure 6.1 World Population Aging, 2009-2025
- Figure 6.2 Number of Over-60s in Selected Countries, 2009 and 2025
- Figure 6.3 AMD Incidence, 2009-2025
- Figure 6.4 Diabetic Retinopathy Incidence Forecast, 2009 and 2025
- Figure 9.1 World AMD & DR Pharmaceutical Market Forecasts, 2010-2025
- Figure 9.2 Lucentis: Revenue Forecast, 2010-2025
Companies Listed
- Alcon (Nestlé)
- Alimera Sciences
- Allergan
- American Academy of Ophthalmology (AAO)
- American Society of Retinal Specialists (ASRS)
- Association for Research in Vision and Ophthalmology (ARVO)
- AstraZeneca
- Bausch & Lomb
- Bayer
- BioDiem
- Bristol-Myers Squibb
- British Medical Journal (BMJ)
- Centers for Medicare and Medicaid Services (CMS) [US]
- Centre for Molecular and Vascular Biology, KU Leuven
- Chugai
- CoMentis
- Diabetic Retinopathy Clinical Research Network (DRCR) [US]
- Eli Lilly
- Emory University
- ESBATech
- Esteve
- European Medicines Agency (EMEA)
- Eyetech (acquired by OSI Pharmaceuticals, 2005)
- Eyetech (corporation formed in 2008)
- Food and Drug Administration (FDA) [US]
- Fovea
- Gene Signal
- Genentech (acquired by Roche, 2009)
- GenVec
- Gilead
- GlaxoSmithKline (GSK)
- iCo
- Isis
- Jerini Ophthalmic
- KAI Pharmaceuticals
- Lpath
- Ludwig-Maximilians-Universität [Germany]
- MacuSight
- Medicare
- Merck & Co.
- Moorfields Eye Hospital [UK]
- National Eye Institute (NEI), part of the National Institutes of Health (NIH) [US]
- National Health Service (NHS) [UK]
- National Institute for Health and Clinical Excellence (NICE) [UK]
- National Institute for Health Research (NIHR) [UK]
- National Institutes of Health (NIH) [US]
- Neurotech
- NeXstar (acquired by Gilead, 1999)
- Novartis
- OM Pharmaceuticals
- Ophthotech
- Opko
- OSI Pharmaceuticals
- Othera Pharmaceuticals
- Oxford BioMedica
- Oxigene
- Pfizer
- Pharmaceutical Benefits Service (PBS) [Australia]
- Potentia
- pSivida
- QLT
- Quark
- Regeneron
- Retinagenix
- Roche
- Santen
- Sanwa Kagaku Kenkyusho (subsidiary of Suzuken)
- Shire
- Sirion Therapeutics
- Sirna Therapeutics
- Sirnaomics
- Suzuken
- Symphony ViDA
- Takeda
- TargeGen
- Targeted Genetics
- ThromboGenics
- University College London
- University of Florida
- University of Kentucky College of Medicine
- US Census Bureau
- Vitreoretinal Technologies
- World Health Organization (WHO)
- Wyeth (now part of Pfizer)

Pharmaceutical Market Research

Macular Degeneration (AMD) and Diabetic Retinopathy Pharmaceutical Market