DNA Sequencing: Emerging Technologies and Applications

Product Code BCC00202
Publication Date July 2010
Publisher BCC Research
Product Type Report
Pages 297
ISBN Number not applicable
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DNA Sequencing: Emerging Technologies and Applications

The goal for this study is to determine the status of current and newer generation DNA (deoxyribonucleic acid) sequencing technologies, products and services and to assess their worldwide growth potential over a 5-year period from 2010 to 2015. Our particular interest is to characterize and quantify the DNA sequencing products market by application, technology, analysis type, geography, and end user.

Highlights:

  • The worldwide market for sequencing products will grow from an estimated $1.3 billion in 2010 to more than $3.3 billion by 2015, a compound annual growth rate (CAGR) of 20.5% over the next 5 years.
  • Life-science research and drug discovery and development applications represent the two largest markets for DNA sequencing revenues, accounting for an estimated $920.1 million in 2010. These markets are forecast to grow at a compound annual growth rate (CAGR) of 13% to reach nearly $1.7 billion in 2015.
  • Emerging applications, including personal genomics and clinical diagnostics, are forecast to account for $541.4 million by the year 2015, an increase from $15.5 million in 2010 representing a 103.5% compound annual growth rate (CAGR).

Contents

  • Chapter- 1: Introduction -- Complimentary
    • Study Goals And Objectives
    • Reasons For Doing The Study
    • Intended Audience
    • Scope Of Report
    • Methodology
    • Information Sources
    • Related Bcc Reports
    • Analyst Credentials
    • Bcc Online Services
    • Disclaimer
  • Chapter-2: Executive Summary
    • Summary Table Global Value Of Dna Sequencing Products, By End-Use Application, Through 2015 ($ Millions)
    • Summary Figure Global Value Of Dna Sequencing Products, By End-Use Application, 2009-2015 ($ Millions)
    • Executive Summary (Continued)
  • Chapter-3: Overview
    • Introduction
    • Table 1 Scope Of This Report
    • Market Potential Of Dna Sequencing Products
    • Table 2 Global Value Of Dna Sequencing Workflow Products, By Type, Through 2015 ($ Millions)
    • Sequencing Industry Growth Driving Forces
    • Table 3 Dna Sequencing Key Growth Driving Forces
    • Sequencing Industry Growth … (Continued)
    • Sequencing Products
    • Sequencing Instruments
    • Sequencing Consumables
    • Sequencing Product Life Cycle Status
    • Table 4 Product Life Cycle Status Of Sequencing Platforms
    • Commercial Status
    • Sequencing Industry
    • Table 5 Sequencing Instrument Competitors, By Technology
    • Sequencing Industry (Continued)
  • Chapter-4: Dna Sequencing Technologies
    • Genetic Analysis
    • Figure 1 Central Molecular Biology Dogma
    • Figure 2 Dna, Mrna, And Genetic Variation
    • Table 6 Scope Of Key Genetic Analysis Technologies
    • Genetic Analysis (Continued)
    • History Of Dna Sequencing
    • Table 7 Dna Sequencing Historical Timeline
    • Table 7 (Continued)
    • History Of Dna Sequencing (Continued)
    • History Of Dna Sequencing (Continued)
    • History Of Dna Sequencing (Continued)
    • Figure 3 Sequencing Cost Trend, Base Pairs Sequenced Per Dollar
    • Figure 4 Sequencing Throughput Trend
    • Figure 5 Human Genome Sequencing Cost Trend, 2000-2015 (Dollars)
    • Figure 6 $1,000 Genome Product Space
    • Overview Of Sequencing Technologies
    • Table 8 Dna Sequencing Technology Platform Comparison
    • Sanger Sequencing
    • Sanger Sequencing Technology
    • Figure 7 Ddntp Chemical Structure
    • Figure 8 Sanger Sequencing Workflow
    • Sanger Sequencing Costs
    • Figure 9 Cost Breakdown For Sequencing A Single Human Genome, Using 2005 Sanger Sequencer Technology (%)
    • Limitations Of Sanger Sequencing
    • Table 9 Limitations Of Sanger Sequencing Technology
    • Technology Developments In Sanger Sequencing
    • Table 10 Improvements In Sanger Sequencing Technology
    • Next-Generation Sequencing Technologies
    • Introduction
    • Next-Generation Sequencing Workflow
    • Table 11 Next-Generation Sequencing Workflow Steps
    • Figure 10 Next-Generation Sequencing Technologies
    • Next-Generation Sequencing … (Continued)
    • Table 12 Workflow Comparison Of Selected Next-Generation Dna Sequencing Platforms
    • Table 13 Next-Generation Sequence Platforms
    • Figure 11 Schematic Comparison Of Roche/454, Life Technologies, And Illumina Sequencing Platforms
    • Table 14 Next-Generation Sequencing Platform Advantages And Limitations
    • Sequencing By Synthesis With Reversible Terminators
    • Figure 12 Sequencing By Synthesis: Reversible Terminator Reaction
    • Pyrosequencing
    • Figure 13 Sequencing By Synthesis: Pyrosequencing Reaction
    • Sequencing By Ligation
    • Sample Preparation
    • Sequencing Reaction
    • Figure 14 Schematic Of Solid Sequencing By Ligation
    • Cycle 1
    • Cycle 2
    • Cycles 3 To 5
    • Decoding
    • Figure 15 Decoding Solid Color Data
    • Third-Generation Sequencing
    • Single-Molecule Sequencing By Synthesis
    • Nanopore Sequencing
    • Figure 16 Single-Molecule Sequencing By Synthesis
    • Nanopore Sequencing (Continued)
    • Nanopore Sequencing (Continued)
    • Figure 17 Nanopore Sequencing Workflow And Technology Approaches
    • Nanopore Sequencing (Continued)
    • Sequencing Technology Platforms Compared
    • Table 15 Key Performance Metrics For Sequencing Technologies
    • Table 16 Cost And Performance Comparison Of Selected Next- And Third-Generation Dna Sequencing Platforms
    • Sequencing Technology … (Continued)
    • Sequencing Product Life Cycle
    • Table 17 Life Cycle Of Dna Sequencing Technologies
    • Sequencing Instrument Cumulative Installed Base
    • Figure 18 Global Cumulative Installed Base Of Dna Sequencers, Through April 2010 (%)
    • Sequence Read Length
    • Table 18 Read Lengths For Selected Sequencing Platforms
    • Sequencer Performance Space
    • Figure 19 Sequencing Competitive Market Space
    • End-User Switching
    • Paired-End Reads
    • Table 19 Strengths And Limitations Of Paired-End Reads
    • Barcoding
    • Dna Polymerases
    • Sequencing Bioinformatics
    • Table 20 Informatics Workflow For Next-Generation Sequencing
    • Technology Challenges For Next-Generation Platforms
    • Table 21 Technology Challenges For Next-Generation Sequencing
    • Technology Challenges … (Continued)
  • Chapter-5: Dna Sequencing Applications
    • Introduction
    • Figure 20 Whole Genome Sequencing Projects For Prokaryotes And Eukaryotes, As Of April 2010 (Number Of Genomes Sequenced)
    • Figure 20 (Continued)
    • Figure 21 Whole Genome Sequencing Eukaryotic Projects, By Type, As Of April 2010
    • Figure 21 (Continued)
    • Research And Drug Discovery Applications
    • Introduction
    • Introduction (Continued)
    • Table 22 Genetic Analysis Formats Comparison
    • Table 23 Sequencing Applications
    • Table 24 De Novo Versus Resequencing Requirements
    • De Novo Sequencing
    • De Novo Human Sequencing
    • De Novo Microbial Sequencing
    • Table 25 Case Study 1: Neanderthal Dna Sequencing
    • Resequencing
    • Whole Genome Resequencing (Genome-Wide Association Studies Or Loci Discovery)
    • Figure 22 Relative Number Of Disease-Causing Alleles At Maf5 And Maf1
    • Figure 23 Single Sequencer, Whole Genome Throughput Trends 1975-2015
    • Targeted Resequencing
    • Seq-Based Methods
    • Table 26 Genetic Analysis Applications Where Sequencing Competes With Microarrays
    • Chromatin Immunoprecipitation Applications
    • Table 27 Comparison Of Sequencing With Microarrays For Chip Applications
    • Dnase-Seq
    • Gene Expression Analysis
    • Table 28 Comparison Of Sequencing And Microarrays For Gene Expression Analysis
    • Methylseq
    • Dna Mutation Studies
    • Complementary Sequencing And Microarray Platforms Drive Market Growth
    • Diagnostics And Drug Discovery
    • Figure 24 Applications Space With Intense Technology Competition
    • Figure 25 Applications Space With Intense Technology Competition
    • Diagnostics And Drug Discovery (Continued)
    • Diagnostics And Drug Discovery (Continued)
    • Personal Genomics
    • Figure 26 Genetic Analysis Cost/Information Content Trends
  • Chapter-6: Dna Sequencing Initiatives
    • Introduction
    • Figure 27 Nih Funding Awards, By Institute, For Dna Sequencing – Related Projects, 2009-2010 (%)
    • Nhgri $1,000 Genome Project Funding
    • Table 29 Nhgri Grants Under $1,000 Genome Program, Fy2009 ($)
    • Figure 28 Nhgri $1,000 Genome Project Awards Value, Fy2007- Fy2009 ($ Millions)
    • Figure 29 $1,000 Genome Project Awards, By Technology, 2007-2009 (%)
    • Sequencing-Related Genomics Projects Overview And Status
    • Table 30 Important Sequencing Research Initiatives
    • Table 30 (Continued)
    • Table 30 (Continued)
    • Genome Sequencing Projects
    • Functional Genomics In Norway (Fuge) Ii
    • Personal Genome Project
    • Archon X Prize In Genomics
    • Genomes 10k Project
    • 1,000 Plant And Animal Reference Project
    • Medical Sequencing Projects
    • Mapped Autosomal Mendelian Disorders
    • Allelic Spectrum In Common Disease Program
    • Clinseq Project
    • Cancer Sequencing Projects
    • Cancer Genome Project
    • Tumor Sequencing Project (Tsp)
    • The Cancer Genome Atlas
    • Microbial Sequencing Projects
    • Human Microbiome Project
    • Microbial Genome Sequencing Project
    • Marine Microbial Genome Sequencing Project
    • Fungal Genome Initiative
    • Pathogen Sequencing Program
    • Genomic Encyclopedia Of Bacteria And Archaea (Geba)
    • Metagenomics Of The Human Intestinal Tract (Metahit)
    • Gut Microbiome Initiative
    • 10,000 Microbial Genomes Project
    • Genome Variation Projects
    • Encyclopedia Of Dna Elements (Encode)
    • 1,000 Genomes Project
    • 1,000 Plant Genomes Project
    • Resequencing Technology Program
    • Human Genome Structural Variation Project
    • Yanhuang Project
    • Agricultural Genomics
    • National Plant Genome Initiative
    • Epigenomics Sequencing Projects
    • Table 31 Epigenomics Initiatives
    • Table 31 (Continued)
    • Europe
    • United States
    • United States (Continued)
    • Asia
    • Impact Of Sequencing Projects
    • Figure 30 Growth In Base Pairs Deposited In Genbank, 1988-2008 (Billions)
  • Chapter-7: Dna Sequencing Industry Structure
    • Industry Structure Analysis
    • Figure 31 Dna Sequencing Industry Structure, 1995-2005
    • Figure 32 Dna Sequencing Industry Structure: Post 2005
    • Industry Structure Analysis (Continued)
    • Table 32 Dna Sequencing Industry Transition
    • The Role Of Early Adaptors
    • Sequencing Instrument Competitor Positioning
    • Figure 33 Sequencer Platform Positioning By Reads And Read Length
    • Table 33 Sequencing Instrument Competitors, By Technology
    • Table 33 (Continued)
    • Sequencing Instrument … (Continued)
    • Sequencing Instrument … (Continued)
    • Sequencing Sample Preparation Industry
    • Table 34 Positioning Of Sequence Enrichment Formats
    • Table 35 Sequencing Sample Preparation Company Positioning
    • Sequencing Sample … (Continued)
    • Sequencing Bioinformatics Industry
    • Table 36 Dna Sequencing Bioinformatics Company Positioning
    • Sequencing Services Industry
    • Table 37 Dna Sequencing Services Company Positioning, By Market Focus
    • Sequencing Instruments Competitor Market Shares
    • Figure 34 Estimated Competitor Market Share: Sequencing Instruments And Reagents, 2009 (%)
    • Figure 34 (Continued)
    • Figure 35 Estimated Competitor Market Share: Sanger Sequencing Instruments And Reagents, 2009 (Total Market $466.2 Million) (%)
    • Figure 35 (Continued)
    • Figure 36 Estimated Competitor Market Share: Next-Generation Sequencing Instruments And Reagents, 2009 (Total Market $607.4 Million) (%)
    • Sequencing Instruments … (Continued)
    • Industry Acquisitions And Strategic Alliances
    • Table 38 Sequencing Industry Acquisitions, 2007-2010
    • Industry Acquisitions … (Continued)
    • Table 39 Sequencing Industry Strategic Alliances, 2007-2010
    • Industry Acquisitions … (Continued)
    • Industry Acquisitions … (Continued)
    • Sequencing Reagents Supply Alliances
    • Personal Genomics Industry Dynamics
    • Table 40 Medium To High Content Dtc Genetic Testing Key Competitors
    • Figure 37 Personal Genomics Competitive Space, By Test Cost And Scope
    • Table 41 Personal Genomics Competitor Strategies
    • Personal Genomics … (Continued)
    • Dna Sequencing End Users
    • Table 42 Dna Sequencing End-User Market Segments
    • Major Sequencing Centers
    • Table 43 Next-Generation Sequencing Instrument Installations, By Major Sequencing Center, 2010
    • Major Sequencing Centers (Continued)
    • Figure 38 Major Sequencing Center's Share Of The Genome Sequencing Projects Market By Number Of Sequencing Projects, April 2010 (%)
    • Figure 39 Beijing Genomics Institute Adoption Of Next-Generation Sequencers, 2008 And 2010 (Number Of Sequencers)
    • Large Core Sequencing Centers
    • Table 44 Examples Of Large Core Sequencing Centers
    • Small To Mid-Size Laboratories
    • Sequencing Service Laboratories
    • Sequencing Service … (Continued)
  • Chapter-8: Dna Sequencing Markets
    • Growth Driving Forces
    • Table 45 Dna Sequencing Key Growth Driving Forces
    • Growth Driving Forces (Continued)
    • Growth Driving Forces (Continued)
    • Figure 40 Eukaryotic Sequencing Paradigm
    • Genetic Analysis Markets
    • Table 46 Global Value Of Genetic Analysis Market, By Analysis Type, Through 2015 ($ Millions)
    • Figure 41 Snp Genotyping Market
    • Genetic Analysis Markets (Continued)
    • Dna Sequencing Products Markets
    • Dna Sequencing Markets By Product Type
    • Table 47 Global Value Of Dna Sequencing Workflow Products, By Type, Through 2015 ($ Millions)
    • Dna Sequencing … (Continued)
    • Table 48 Global Value Of Dna Sequencing Instrument And Consumables Market, By Product Type, Through 2015 ($ Millions)
    • Dna Sequencing Markets By Sanger And Next-Generation Formats
    • Figure 42 Global Value Of Sequencing Instruments And Consumables, By Technology Platform, 2010 And 2015 (Dollars)
    • Figure 42 (Continued)
    • Table 49 Global Value Of Dna Sequencing Instruments, By Platform, Through 2015 ($ Millions)
    • Table 50 Global Value Of Dna Sequencing Consumables Market, By Platform, Through 2015 ($ Millions)
    • Dna Sequencing Markets By End User
    • Table 51 Global Value Of Dna Sequencing Instruments And Consumables, By Customer Type, Through 2015 ($ Millions)
    • Dna Sequencing … (Continued)
    • Table 52 Global Value Of Sanger Sequencing Instruments And Consumables, By Customer, Through 2015 ($ Millions)
    • Table 53 Global Value Of Next-Generation Sequencing Instruments And Consumables, By Customer, Through 2015 ($ Millions)
    • Dna Sequencing Markets By Technology
    • Table 54 Global Value Of Dna Sequencing Instruments And Consumables Market, By Technology, Through 2015 ($ Millions)
    • Dna Sequencing Markets By End-User Application
    • Table 55 Global Value Of Dna Sequencing, By End-Use Application, Through 2015 ($ Millions)
    • Research And Drug Discovery And Development
    • Forensic And Human Id
    • Bacterial Genomics
    • Agricultural Genomics
    • Clinical Diagnostics
    • Table 56 Laboratories Developing Next-Generation Sequencing Dx Tests
    • Personal Genomics
    • Personal Genomics (Continued)
    • Other Applications
    • Table 57 Global Value Of Next-Generation Sequencing Instruments And Consumables, By End-Use Application, Through 2015 ($ Millions)
    • Other Applications (Continued)
    • Table 58 Global Value Of Sanger Sequencing Instruments And Consumables, By End-Use Application, Through 2015 ($ Millions)
    • Dna Sequencing Markets By Genome Type
    • Table 59 Global Value Of Sequencing, By Genome Type, Through 2015 ($ Millions)
    • Dna Sequencing Markets (Continued)
    • Dna Sequencing Markets By Analysis Type
    • Table 60 Global Value Of Dna Sequencing, By Analysis Type, Through 2015 ($ Millions)
    • Table 61 Global Value Of Next-Generation Sequencing, By Analysis Type, Through 2015 ($ Millions)
    • Table 62 Global Value Of Sanger Sequencing, By Analysis Type, Through 2015 ($ Millions)
    • Dna Sequencing Markets By Geography
    • Table 63 Global Value Of Dna Sequencing Products, By Geographical Market, Through 2015 ($ Millions)
    • Table 64 Global Value Of Sanger Sequencing Products, By Geographical Market, Through 2015 ($ Millions)
    • Table 65 Global Value Of Next-Generation Sequencing Products, By Geographical Market, Through 2015 ($ Millions)
    • Dna Sequencing Markets … (Continued)
  • Chapter-9: Dna Sequencing Patent Status
    • Recent Patent Activity In Next-Generation Dna Sequencing
    • Table 66 Next-Generation Sequencing Patent Recent Activity
    • Table 66 (Continued)
    • Sequencing By Synthesis
    • Single-Molecule Sequencing
    • Nanopore Sequencing
    • Polony Sequencing
    • Nucleotide Modifications And Analogs
    • Dna Polymerases
    • Paired-End Inventions
    • Other Methods
    • Patent Position Of Sequencing Competitors
    • Figure 43 Sequencing-Related Patents, By Company (Number Of Patents)
    • Figure 43 (Continued)
    • Technology Distribution Of Next-Generation Sequencing Patents
    • Figure 44 Global Next-Generation Sequencing Patents, By Technology, 2001-2009
    • Geographical Distribution Of Next-Generation Sequencing Patents
    • Figure 45 Global Next-Generation Sequencing-Related Patents, By Geography, 2000-2009 (Number Of Patents)
    • Sequencing Litigation Status
    • Table 67 Sequencing Ip Litigation Status
    • Sequencing Litigation Status (Continued)
    • Intellectual Property Position Of Selected Sequencing Companies
    • Life Technologies
    • Li-Cor Biosciences
    • Helicos Biosciences
    • Illumina
    • Intelligent Bio-Systems
    • Pacific Biosciences
  • Chapter-10: Company Profiles
    • 23andme
    • Affomix Corporation
    • Affymetrix, Inc
    • Agilent Technologies, Inc
    • Agilent Technologies, Inc. (Continued)
    • Artemis Health, Inc
    • Base4innovation, Ltd
    • Beckman Coulter
    • Beckman Coulter (Continued)
    • Bio.Logis Center For Human Genetics
    • Bionanomatrix, Inc
    • Biotique Systems Inc
    • Caliper Life Sciences
    • Caliper Life Sciences (Continued)
    • Caliper Life Sciences (Continued)
    • Collabrx, Inc
    • Complete Genomics, Inc
    • Conexio Genomics
    • Correlagen Diagnostics, Inc
    • Danaher Motion
    • Decodeme
    • Deltadot, Ltd
    • Dnanexus, Inc
    • Dna Star, Inc
    • Electronic Biosciences
    • Eurofins Medigenomix Gmbh
    • Expression Analysis, Inc
    • Fasteris Sa
    • Febit Biotech Gmbh
    • Firebird Biomolecular Sciences, Llc
    • Fluidigm Corporation
    • Fluidigm Corporation (Continued)
    • Foundation For Applied Molecular Evolution
    • Gatc Biotech Ag
    • Ge Healthcare
    • Genedata Ag
    • Genome Diagnostics B.V
    • Genomequest, Inc
    • Genomatix Software, Inc
    • Genovoxx Gmbh
    • Geospiza, Inc
    • Halcyon Molecular
    • Helicos Biosciences Corporation
    • International Business Machines Corp
    • Illumina, Inc
    • Illumina, Inc. (Continued)
    • Table 68 Illumina Sequencing Technology Space
    • Industrial Technology Research Institute
    • Intelligent Bio-Systems
    • Interna Genomics Bv
    • Ion Torrent Systems
    • Ip Genesis Inc
    • Isentio As
    • Knome, Inc
    • Lasergen, Inc
    • Li-Cor Biosciences
    • Life Technologies, Inc
    • Life Technologies, Inc. (Continued)
    • Life Technologies, Inc. (Continued)
    • Lifecodexx
    • Lightspeed Genomics
    • Lingvitae As
    • Microchip Biotechnologies, Inc
    • Mwg Biotech Ag
    • Mycroarray.Com
    • Nabsys, Inc
    • Navigenics
    • Network Biosystems
    • Newgene, Ltd
    • Nugen Technologies, Inc
    • Olink Genomics Ab
    • Opgen, Inc
    • Oxford Nanopore Technologies
    • Pacific Biosciences
    • Pacific Biosciences (Continued)
    • Population Genetics Technologies, Ltd
    • Quantalife, Inc
    • Raindance Technologies, Inc
    • Real Time Genomics
    • Reveo Inc
    • Roche Life Sciences
    • Roche Life Sciences (Continued)
    • Roche Life Sciences (Continued)
    • Seirad, Inc
    • Sequenom, Inc
    • Sequenom, Inc. (Continued)
    • Sequenom, Inc. (Continued)
    • Seqwright
    • Shimadzu Scientific Instruments
    • Smartgene
    • Source Biosciences, Plc
    • Sorenson Genomics
    • U.S. Genomics
    • Visigen Biotechnologies, Inc
    • X-Prize Foundation
    • Zs Genetics
    • Zs Genetics (Continued)
    • Zs Genetics (Continued)